Neuromedin U and Its Putative Drosophila Homolog hugin
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چکیده
منابع مشابه
Neuromedin U and Its Putative Drosophila Homolog hugin
Christoph Melcher, Rüdiger Bader, Steffen Walther, Oleg Simakov, Michael J. Pankratz We recently provided a molecular, neuroanatomical, and behavioral analyses of neurons expressing the neuropeptide gene hugin in Drosophila [1]. hugin-expressing neurons appear to comprise a neural circuitry in the brain that modulates feeding behavior in response to gustatory and nutrient signals. One of the qu...
متن کاملNeuromedin U and its receptors: structure, function, and physiological roles.
Neuromedin U (NmU) is a structurally highly conserved neuropeptide. It is ubiquitously distributed, with highest levels found in the gastrointestinal tract and pituitary. Originally isolated from porcine spinal cord, it has since been isolated and sequenced from several species. Amino acid alignment of NmU from different species reveals a high level of conservation, and particular features with...
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Neuromedin U (NMU) was originally identified as an anorexigenic peptide that modulates appetite as well as energy homeostasis through the brain-gut axis. Although growing evidence has linked NMU activity with the development of female reproductive organs, no direct expression of and function for NMU in these organs has been pinpointed. Using a superovulated rat model, we found that NMU is direc...
متن کاملHypothalamic actions of neuromedin U.
The central nervous system and gut peptide neuromedin U (NMU) inhibits feeding after intracerebroventricular injection. This study explored the hypothalamic actions of NMU on feeding and the hypothalamo-pituitary-adrenal axis. Intraparaventricular nucleus (intra-PVN) NMU dose-dependently inhibited food intake, with a minimum effective dose of 0.1 nmol and a robust effect at 0.3 nmol. Feeding in...
متن کاملA putative Drosophila homolog of the Huntington's disease gene.
The Huntington's disease (HD) gene encodes a protein, huntingtin, with no known function and no detectable sequence similarity to other proteins in current databases. To gain insight into the normal biological role of huntingtin, we isolated and sequenced a cDNA encoding a protein that is a likely homolog of the HD gene product in Drosophila melanogaster. We also determined the complete sequenc...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2006
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.0040068